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KMID : 1031120160060010039
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Journal of Epilepsy Research
2016 Volume.6 No. 1 p.39 ~ p.41
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Supra-recommendation Treatment of Super-refractory Status Epilepticus
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Vyas Devashish Dhiren
Dash Gopal Krishna
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Abstract
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A 28-year old female was admitted with recurrent seizures following 2 days of febrile illness, after which she developed status epilepticus. Midazolam and later thiopentone infusions were started after failure of regular intravenous antiepileptics. Burst suppression was achieved at doses of 3 mg/kg/hr for midazolam and 6 mg/kg/hr of thiopentone. Adjunctive medications included methylprednisolone, intravenous immunoglobulin and acyclovir. Imaging and biochemical parameters were normal. She required 3 cycles of midazolam and 2 cycles of thiopentone for complete cessation of seizures. She recovered with mild attentional and recent memory deficits on follow up. Treatment of super-refractory status epilepticus requires individualized regimens and may need doses beyond conventional limits. To the best of our knowledge, there is no such reported case from India.
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KEYWORD
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Status epilepticus, Treatment, Antiepileptics, Anesthetic agents, Autoimmune
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